Why take this exam
Hereditary gynecological cancer is characterized by its incidence in individuals under the age of 40 years. In women, represents between the 5-15% of cases of this type of cancer. The origin of this genetic susceptibility frequently consists of mutations in the BRCA1 and BRCA2 genes., although there are other genes related to breast cancer, ovary and endometrium that must be studied to provide more complete information to complement the medical analysis.
What is the exam?
The BRCA test + 16 genes is an analysis of the patient's DNA by next generation sequencing – NGS (Next generation sequencing) to detect point mutations and small insertions/deletions in 18 genes (ATM, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, (For example, in the case of patients with cervical cancer). Additionally, the MLPA technique is performed (Múltiple Lipe Probe Amplification) of BRCA1 genes, BRCA2 and EPCAM for the detection of large deletions and duplications.
Who is it indicated for??
- Women with more than 30 years without record, as a preventive measure against breast and/or ovarian cancer.
• Women with a family history of breast cancer (masculine or feminine) and/or ovary.
• Family member carrying a BRCA1 or BRCA2 mutation.
• Patients who suffer from this type of tumor, in order to determine your possible hereditary profile.
Technology
Next generation sequencing (NGS) y Múltiple Ligation Probe Amplification (MLPA)
Advantages
SYNLAB GROUP: Guaranteed by the experience of the Synlab group, absolute European leader in laboratory diagnostics.
BROAD:Complete genetic study of genes related to hereditary gynecological cancer and not only the BRCA1 and BRCA2 genes.
GENETIC COUNSELING:Genetic counseling available at no cost according to the client's need.
EXTENSIVE DATABASE:Changes found in the most complete and updated databases (Free the data).
RELIABLE:Any pathogenic mutation or mutation of uncertain significance is verified by a new DNA extraction followed by Sanger sequencing, which also guarantees the 100% coverage of all bases read from DNA.
Additional Information
DOCUMENTATION: Available on the Extranet for clients:
• Informed consent.
• Clinical Petitioner.
PREPARATION: •It is not necessary to remain fasting to perform the test.
Delivery time 11 Work days
